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[blackgoku]

Jak widać skuteczny lek przeciw CoV-19 istnieje.

Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction.
Ho TY1, Wu SL, Chen JC, Li CC, Hsiang CY.
Author information
Abstract

Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus (SARS-CoV). SARS-CoV spike (S) protein, a type I membrane-bound protein, is essential for the viral attachment to the host cell receptor angiotensin-converting enzyme 2 (ACE2). By screening 312 controlled Chinese medicinal herbs supervised by Committee on Chinese Medicine and Pharmacy at Taiwan, we identified that three widely used Chinese medicinal herbs of the family Polygonaceae inhibited the interaction of SARS-CoV S protein and ACE2. The IC(50) values for Radix et Rhizoma Rhei (the root tubers of Rheum officinale Baill.), Radix Polygoni multiflori (the root tubers of Polygonum multiflorum Thunb.), and Caulis Polygoni multiflori (the vines of P. multiflorum Thunb.) ranged from 1 to 10 microg/ml. Emodin, an anthraquinone compound derived from genus Rheum and Polygonum, significantly blocked the S protein and ACE2 interaction in a dose-dependent manner. It also inhibited the infectivity of S protein-pseudotyped retrovirus to Vero E6 cells. These findings suggested that emodin may be considered as a potential lead therapeutic agent in the treatment of SARS.

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Novel coronavirus receptors show similarities to SARS-CoV, according to new analysis

Date:
January 31, 2020
Source:
American Society for Microbiology
Summary:
Previous studies have shown how the SARS virus (SARS-CoV) interacts with animal and human hosts in order to infect them. The mechanics of infection by the Wuhan coronavirus appear to be similar.
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FULL STORY

The recent emergence of Wuhan coronavirus (2019-nCoV) has put the world on high alert for transcontinental transmission, reminiscent of the outbreak of SARS -- also a coronavirus -- in 2002-2003.

Decade-long structural studies by Fang Li of the University of Minnesota, et al. have shown how the SARS virus (SARS-CoV) interacts with animal and human hosts in order to infect them. The mechanics of infection by the Wuhan coronavirus appear to be similar. These investigators used the knowledge they gleaned from multiple SARS-CoV strains -- isolated from different hosts in different years -- and angiotensin-converting enzyme-2 (ACE2) receptors from different animal species to model predictions for the novel Wuhan coronavirus. (Both viruses use ACE2 to gain entry into the cell, but it serves normally as a regulator for heart function.)

"Our structural analyses confidently predict that the Wuhan coronavirus uses ACE2 as its host receptor," the investigators wrote. That and several other structural details of the new virus are consistent with the ability of the Wuhan coronavirus to infect humans and with some capability to transmit among humans.

"Alarmingly, our data predict that a single mutation [at a specific spot in the genome] could significantly enhance [the Wuhan coronavirus's] ability to bind with human ACE2," the investigators write. For this reason, Wuhan coronavirus evolution in patients should be closely monitored for the emergence of novel mutations at the 501 position in its genome, and to a lesser extent, the 494 position, in order to predict the possibility of a more serious outbreak than has been seen so far.

The research is published in the Journal of Virology, a journal of the American Society for Microbiology. The study provides the basic, translational and public health research communities with predictive insights that may help study and battle this novel coronavirus.

For more information on the new strain of coronavirus, visit ASM's Novel Coronavirus (2019-nCoV) Resources page: https://www.asm.org/Press-Releases/2020 ... -Resources
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Story Source:

Materials provided by American Society for Microbiology. Note: Content may be edited for style and length.

Journal Reference:

Yushun Wan, Jian Shang, Rachel Graham, Ralph S. Baric, Fang Li. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 2020; DOI: 10.1128/JVI.00127-20

[Kobyszcze]

Sporo ziół zawiera emodynę, w tym część z tradycyjnego chińskiego zielnika.
Podpytam znajomych chinoli czy coś wiedzą, czy tam stosowali te zioła u chorych,może jakies dawkowanie czy coś...

[AnnaS]

Skutecznie działa lukrecja stosowali 9g korzenia w ciezkich stanach w lekkich 5g ephedra sinica plus 4g lukrecji.
Dodatkowo dziurawiec również zawiera emodyne.

[blackgoku]

Aloes ma aloeemodynę, ale z aloesem nie przesadzajcie, bo jego z głową trzeba przyjmować. :>

[Kobyszcze]

Chwile trwało
Chińczycy ze swojej medycyny walczą z Cvid19 za pomocą Lianhua qingwen
Emodyna też w tym jest
https://www.hindawi.com/journals/tswj/2015/731765/