Gdy ktoś znów powie Wam, że "nie ma badań"...

Bogdan Jot, autor strony marihuanaleczy.pl, podsuwa niezwykle obszerną ściągawkę na temat "nieistniejących" badań i dowodów odnoszących się do skuteczności medycznej marihuany. Polecamy uwadze.

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Bogdan Jot

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Już za moment (3 II) rozpocznie się kolejna w Polsce konferencja poświęcona medycznym zastosowaniom marihuany. Chyba najbardziej fachowa ze wszystkich dotychczasowych, z udziałem m. in. kilku lekarzy wykorzystujących marihuanę w swej codziennej praktyce. Odbędą się 2 specjalistyczne panele dyskusyjne poświęcone kannabinoidom w walce z bólem i w padaczce dziecięcej – mam nadzieję, że spotkają się z odpowiednim zainteresowaniem naszych lekarzy. To głównie dla nich przygotowałem poniższe dwa wykazy literatury naukowej – takich prac jest zdecydowanie więcej, nawet nie próbowałem znaleźć wszystkich, te miałem akurat w moich notatkach. Ale myślę, że to i tak wystarczy, żeby dać do myślenia zwolennikom poglądu, że nie ma badań.

→ ZWALCZANIE BÓLU

● Amygdala activity contributes to the dissociative effect of cannabis on pain perception – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549497/
● Cannabinergic Pain Medicine: Developing a Concise Clinical Primer and Surveying Randomized-Controlled Trial Results – http://www.jpsmjournal.com/article/S0885-3924(12)00639-2/fulltext
● High hopes for cannabinoid analgesia – http://www.bmj.com/content/329/7460/257
● Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey – https://www.hindawi.com/journals/arp/2009/827290/
● Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain – http://www.jneurosci.org/content/28/46/12125.full
● Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials – http://www.ncbi.nlm.nih.gov/pubmed/25796592/
● The role of the endocannabinoid system in pain – http://www.ncbi.nlm.nih.gov/pubmed/25846617
● Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/
● CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? – http://www.ncbi.nlm.nih.gov/pubmed/12550743
● Cannabinoids and Hallucinogens for Headache – http://onlinelibrary.wiley.com/doi/10.1111/head.12025/abstract
● Peripherally Restricted Cannabinoids for the Treatment of Pain – http://onlinelibrary.wiley.com/doi/10.1002/phar.1642/abstract
● Inhaled Cannabis Shown Effective for Diabetic Neuropathy Pain – http://americanpainsociety.org/about-us/press-room/inhaled-cannabis-show...
● Pain modulation by negative affective state: role of the endocannabinoid system – http://cannabis-med.org/members/wp-content/uploads/2015/11/David-Finn-Pa...
● Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain – http://www.ncbi.nlm.nih.gov/pubmed/19896326
● Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis – https://www.ncbi.nlm.nih.gov/pubmed/26764336
● Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566631/
● Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial – http://www.ncbi.nlm.nih.gov/pubmed/26822791
● Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain – http://www.ncbi.nlm.nih.gov/pubmed/17257464
● The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study – https://www.ncbi.nlm.nih.gov/pubmed/26889611
● Nabilone for the Management of Pain – http://www.ncbi.nlm.nih.gov/pubmed/26923810
● Survey says cannabis patients find pain relief, improved mood – http://www.whig.com/article/20160328/ARTICLE/303289889
● A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2 – http://www.ncbi.nlm.nih.gov/pubmed/26935064
● Combined Treatment with Morphine and Δ9-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal – http://www.ncbi.nlm.nih.gov/pubmed/26937020
● State of the evidence: Cannabinoids and cancer pain-A systematic review – https://www.ncbi.nlm.nih.gov/pubmed/27863159
● The pharmacokinetics, efficacy, safety, and ease of use of a novel portable metered-dose cannabis inhaler in patients with chronic neuropathic pain: a phase 1a study – https://www.ncbi.nlm.nih.gov/pubmed/25118789
● Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been … – http://onlinelibrary.wiley.com/doi/10.1111/head.12570/abstract
● Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066045/
● Cannabis for the Management of Pain: Assessment of Safety Study – http://www.jpain.org/article/S1526-5900(15)00837-8/fulltext
● Effects of Vaporized Marijuana on Neuropathic Pain – Study Results – https://www.clinicaltrials.gov/ct2/show/results/NCT01037088
● An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease – https://www.ncbi.nlm.nih.gov/pubmed/27286745
● Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review – http://www.bmj.com/content/323/7303/13
● Prescribing cannabis for harm reduction – https://harmreductionjournal.biomedcentral.com/articles/10.1186/1477-751...
● Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268094/
● Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755639/
● Cannabinoids for Neuropathic Pain – https://www.ncbi.nlm.nih.gov/pubmed/25160710
● Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243008/
● Cannabinoids in the management of difficult to treat pain – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
● Role of Cannabinoids in Pain Management – http://cannabisclinicians.org/role-of-cannabinoids-in-pain-management/
● Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/
● Smoked cannabis for chronic neuropathic pain: a randomized controlled trial – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/
● Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain – http://www.jpain.org/article/S1526-5900%2812%2900864-4/abstract
● Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice – https://www.ncbi.nlm.nih.gov/pubmed/27214593
● Cannabis as an Adjunct to or Substitute for Opiates in the Treatment of Chronic Pain – http://www.tandfonline.com/doi/abs/10.1080/02791072.2012.684624
● Involvement of the endocannabinoid system in osteoarthritis pain – https://www.ncbi.nlm.nih.gov/pubmed/24494687
● Neuropathic orofacial pain: cannabinoids as a therapeutic avenue – https://www.ncbi.nlm.nih.gov/pubmed/25150831
● Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis – https://www.ncbi.nlm.nih.gov/pubmed/16186518
● Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial – https://www.ncbi.nlm.nih.gov/pubmed/17997224
● The Endocannabinoid System, Cannabinoids, and Pain – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/
● Therapeutic potential of cannabis in pain medicine – http://bja.oxfordjournals.org/content/101/1/59.full
● Use of cannabinoids in cancer care: palliative care – http://www.current-oncology.com/index.php/oncology/article/view/2962/2087
● Why U.S. Doctors Love Opioids and Hate Marijuana for Chronic Pain – http://labblog.uofmhealth.org/rounds/why-us-doctors-love-opioids-and-hat...
● Neuropathic Pain – https://www.projectcbd.org/neuropathic-pain

→ PADACZKA

● Marijuana-Derived Epilepsy Drug in Clinical Trial for Children with Uncontrolled Seizures – http://www.ucsf.edu/news/2014/02/111641/marijuana-derived-epilepsy-drug-...
● The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy – http://jpet.aspetjournals.org/content/307/1/129.long
● Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/25845492
● Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex – https://www.ncbi.nlm.nih.gov/pubmed/27696387
● Cannabidiol: Pharmacology and potential therapeutic rolein epilepsy and other neuropsychiatric disorders – http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/epdf
● The case for medical marijuana in epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/epdf
● The cannabinoids as potential antiepileptics – http://www.ncbi.nlm.nih.gov/pubmed/6975285
● Medical Marijuana Extract Curbs Seizure Frequency in Early Trial of Epilepsy Patients – http://nyulangone.org/press-releases/medical-marijuana-extract-curbs-sei...
● Marijuana use in adults admitted to a Canadian epilepsy monitoring unit – https://www.ncbi.nlm.nih.gov/pubmed/27568641
● Cannabis anti-convulsant shakes up epilepsy treatment – https://www.newscientist.com/article/dn22263-cannabis-anti-convulsant-sh...
● Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures – http://www.seizure-journal.com/article/S1059-1311(12)00057-X/fulltext
● Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol – https://www.ncbi.nlm.nih.gov/pubmed/27267376
● Slim Evidence for Cannabinoids for Epilepsy – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639568/
● Pharmaceutical CBD (cannabidiol) shows promise for children with severe epilepsy – http://www.sciencedaily.com/releases/2015/12/151207145856.htm
● Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial – http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/abstract
● Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases – https://www.ncbi.nlm.nih.gov/pubmed/27655472
● Cannabinoids: is there a potential treatment role in epilepsy? – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845642/
● Cannabinoids for epilepsy – http://www.ncbi.nlm.nih.gov/pubmed/22696383
● CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience – https://www.ncbi.nlm.nih.gov/pubmed/26800377
● Cannabis and other illicit drug use in epilepsy patients – http://www.ncbi.nlm.nih.gov/pubmed/23311572
● Efficacy and safety of epidiolex (cannabidiol) in children and young adults with treatment-resistant epilepsy: update from the expanded access program – https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/241...
● Long-term efficacy and tolerability of add-on cannabidiol for drug-resistant pediatric epilepsies – https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/232...
● Fewer specialists support using medical marijuana andCBD in treating epilepsy patients compared with othermedical professionals and patients: Result of Epilepsia’ssurvey – http://onlinelibrary.wiley.com/doi/10.1111/epi.12843/epdf
● Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/
● The case for medical marijuana in epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/full
● Temporal characterization of changes in hippocampal cannabinoid CB1 receptor expression following pilocarpine-induced status epilepticus – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841984/
● Phytocannabinoids and epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/25475762
● Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients – https://www.ncbi.nlm.nih.gov/pubmed/27859038
● Patient use of cannabis in epilepsy – https://www.sciencedaily.com/releases/2014/12/141208144146.htm
● Medical Marijuana and Epilepsy – http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treat...
● Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol – http://journal.frontiersin.org/article/10.3389/fphar.2016.00359/full
● Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02334.x/full
● Chronic administration of cannabidiol to healthy volunteers and epileptic patients – https://www.ncbi.nlm.nih.gov/pubmed/7413719
● The Pharmacological Basis of Cannabis Therapy for Epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/26787773
● Cannabis and Endocannabinoid Signaling in Epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/26408165
● Cannabidiol: Promise and Pitfalls – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189631/
● Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707667/
● Cannabidiol for Intractable Epilepsy: Promising Open-label Results Increase Interest in Forthcoming Blinded Trials – http://journals.lww.com/neurotodayonline/Fulltext/2016/02040/Cannabidiol...
● AHP Releases Cannabis in the Management and Treatment of Seizures and Epilepsy: A Scientific Review – https://www.naturalproductsinsider.com/news/2014/03/ahp-releases-review-...
● Clinical Experience With Cannabis In Treatment-Resistant Pediatric Epilepsy – http://docplayer.net/21578411-Clinical-experience-with-cannabis-in-treat...
● Cannabis in the Treatment of Pediatric Epilepsy – http://theroc.us/images/Cannabis in the Treatment of Pediatric Epilepsy.pdf
● Endocannabinoid system protects against cryptogenic seizures – https://www.ncbi.nlm.nih.gov/pubmed/21441624
● Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157067/
● Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804326/
● Anti-Convulsant Properties of Cannabis Extract is NOT a New Discovery – http://epilepsyu.com/blog/anti-convulsant-properties-cannabis-extract-ne...
● CENSORED: 1947 Cannabis Study on Epilepsy – http://weedfinder.com/dash/news/censored-1947-cannabis-study-on-epilepsy/

………………..

W sobotę będziemy rozmawiali na temat stosowania kannabinoidów w onkologii. Dla tych od „nie ma badań” też przygotowałem trochę linków – tym razem do stron, na których zbiorczo przedstawiono informacje o różnych badaniach z tego obszaru. Niestety, poza paroma wyjątkami nie są to badania kliniczne. Będę o tym mówił w moim wystąpieniu na konferencji.

→ RAK

● 123 Studies Show Cannabis Prohibition Is Killing Cancer Patients – http://www.exposingtruth.com/123-cannabis-cancer/
● 20 Medical Studies that prove cannabis can cure cancer – http://londoncannabisclub.com/20-medical-studies-prove-cannabis-can-cure...
● 20 Medical Studies That Show Cannabis Can Be A Potential Cure For Cancer – http://www.collective-evolution.com/2013/08/23/20-medical-studies-that-p...
● 34 Studies showing cannabis can cure cancer – http://www.cureyourowncancer.org/cannabis-can-cure-many-forms-of-cancer....
● 4 Studies Proving that Marijuana can Treat Brain Cancer – http://naturalsociety.com/4-studies-marijuana-treat-brain-cancer/
● 64 Studies That Show Cannabis Can Treat Various Cancers – https://thejointblog.com/61-studies-show-cannabis-can-treat-various-canc...
● 68 studies on the efficiency of marijuana against cancer- http://www.alchimiaweb.com/blogen/68-studies-efficiency-marijuana-agains...
● 700 medicinal uses of cannabis sorted by disease – http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
● 9 types of cancer that can be killed by cannabis – http://healthycures.org/9-types-of-cancer-that-can-be-killed-by-cannabis/
● Cannabis Cures – 121 Studies Cannabinoids Kill Cancer cells – http://thecannabiscure.blogspot.com/2015/01/121-studies-cannabinoids-kil...
● Lista 34 badań medycznych dowodzących skuteczność wykorzystywania konopi w terapii nowotworów – http://konopielecza.pl/lista-34-badan-medycznych-dowodzacych-skutecznosc...
● Marihuana leczy raka! – czyli 20 badań medycznych potwierdzających lecznicze właściwości konopi – http://www.medicoland.pl/artykuly/100/marihuana-leczy-rakaczyli-20-badan...
● Over 100 Scientific Studies Agree: Cannabis Annihilates Cancer – http://wakeup-world.com/2015/05/17/over-100-scientific-studies-agree-can...
● The Top 42 Medical Studies That Prove Cannabis Cures Cancer – http://www.hempforfuture.com/2014/05/12/the-top-42-medical-studies-that-...
● There Are Now 100 Scientific Studies That Prove Cannabis Cures Cancer – http://higherperspectives.com/cannabis-cures-cancer/

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Zajawki z NeuroGroove
  • 1P-LSD
  • Tripraport

Dupy nie urywa

Zawsze wykazywałem cholerną tolerancje na wszelakie substancje (oprócz dopalaczy o których wkrótce opowiem) lecz dawka 1mg dawała mi sporo do myślenia. Po długich zastanowieniach postanowiłem jednak tego dokonać. Mój poprzedni rekord to było 500ug gdzie jako tako kontaktowałem, ba jeździłem na rowerze!

  • Dekstrometorfan

Nazwa substancji: Tussidex 30mg (Dextromethorphani hydrobromidum)

Dawka: 900mg (30 tabl.)

Poziom zaawansowania - THC, amfetamina, alkohol, DXM.

set & setting: Jestem wypoczęty, ciesze sie nowym dniem, przyjaźnie nastawiony do świata - lekko zmęczony i zaciekawiony nową, większą dawką DXM.

  • 25C-NBOMe
  • Pozytywne przeżycie

Moje nastawienie było raczej pozytywne. Trochę wątpliwości co do substancji wynikających z opowiadań o bad tripach. Pogoda najlepsza moim zdaniem (początek wiosny) ciepło i słonecznie. Test przeprowadzałem sam.

   Piękny poranek zwiastował jeszcze lepszy dzień. Byłem bardzo podekscytowany, czekałem na moje 25c od paru dni, a sms o jego dostarczeniu paczkomatu przyszedł już dzień wcześniej. Ja i mój kumpel (K) byliśmy umówieni w mieście na test specyfiku.