Gdy ktoś znów powie Wam, że "nie ma badań"...

Już za moment (3 II) rozpocznie się kolejna w Polsce konferencja poświęcona medycznym zastosowaniom marihuany. Chyba najbardziej fachowa ze wszystkich dotychczasowych, z udziałem m. in. kilku lekarzy wykorzystujących marihuanę w swej codziennej praktyce. Odbędą się 2 specjalistyczne panele dyskusyjne poświęcone kannabinoidom w walce z bólem i w padaczce dziecięcej – mam nadzieję, że spotkają się z odpowiednim zainteresowaniem naszych lekarzy. To głównie dla nich przygotowałem poniższe dwa wykazy literatury naukowej – takich prac jest zdecydowanie więcej, nawet nie próbowałem znaleźć wszystkich, te miałem akurat w moich notatkach. Ale myślę, że to i tak wystarczy, żeby dać do myślenia zwolennikom poglądu, że nie ma badań.

→ ZWALCZANIE BÓLU

● Amygdala activity contributes to the dissociative effect of cannabis on pain perception – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549497/
● Cannabinergic Pain Medicine: Developing a Concise Clinical Primer and Surveying Randomized-Controlled Trial Results – http://www.jpsmjournal.com/article/S0885-3924(12)00639-2/fulltext
● High hopes for cannabinoid analgesia – http://www.bmj.com/content/329/7460/257
● Tetrahydrocannabinol (Delta 9-THC) Treatment in Chronic Central Neuropathic Pain and Fibromyalgia Patients: Results of a Multicenter Survey – https://www.hindawi.com/journals/arp/2009/827290/
● Crucial Role of CB2 Cannabinoid Receptor in the Regulation of Central Immune Responses during Neuropathic Pain – http://www.jneurosci.org/content/28/46/12125.full
● Cannabinoids for the Treatment of Chronic Non-Cancer Pain: An Updated Systematic Review of Randomized Controlled Trials – http://www.ncbi.nlm.nih.gov/pubmed/25796592/
● The role of the endocannabinoid system in pain – http://www.ncbi.nlm.nih.gov/pubmed/25846617
● Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/
● CB2 cannabinoid receptor agonists: pain relief without psychoactive effects? – http://www.ncbi.nlm.nih.gov/pubmed/12550743
● Cannabinoids and Hallucinogens for Headache – http://onlinelibrary.wiley.com/doi/10.1111/head.12025/abstract
● Peripherally Restricted Cannabinoids for the Treatment of Pain – http://onlinelibrary.wiley.com/doi/10.1002/phar.1642/abstract
● Inhaled Cannabis Shown Effective for Diabetic Neuropathy Pain – http://americanpainsociety.org/about-us/press-room/inhaled-cannabis-show...
● Pain modulation by negative affective state: role of the endocannabinoid system – http://cannabis-med.org/members/wp-content/uploads/2015/11/David-Finn-Pa...
● Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain – http://www.ncbi.nlm.nih.gov/pubmed/19896326
● Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis – https://www.ncbi.nlm.nih.gov/pubmed/26764336
● Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566631/
● Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial – http://www.ncbi.nlm.nih.gov/pubmed/26822791
● Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain – http://www.ncbi.nlm.nih.gov/pubmed/17257464
● The Effect of Medicinal Cannabis on Pain and Quality-of-Life Outcomes in Chronic Pain: A Prospective Open-label Study – https://www.ncbi.nlm.nih.gov/pubmed/26889611
● Nabilone for the Management of Pain – http://www.ncbi.nlm.nih.gov/pubmed/26923810
● Survey says cannabis patients find pain relief, improved mood – http://www.whig.com/article/20160328/ARTICLE/303289889
● A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2 – http://www.ncbi.nlm.nih.gov/pubmed/26935064
● Combined Treatment with Morphine and Δ9-Tetrahydrocannabinol in Rhesus Monkeys: Antinociceptive Tolerance and Withdrawal – http://www.ncbi.nlm.nih.gov/pubmed/26937020
● State of the evidence: Cannabinoids and cancer pain-A systematic review – https://www.ncbi.nlm.nih.gov/pubmed/27863159
● The pharmacokinetics, efficacy, safety, and ease of use of a novel portable metered-dose cannabis inhaler in patients with chronic neuropathic pain: a phase 1a study – https://www.ncbi.nlm.nih.gov/pubmed/25118789
● Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been … – http://onlinelibrary.wiley.com/doi/10.1111/head.12570/abstract
● Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066045/
● Cannabis for the Management of Pain: Assessment of Safety Study – http://www.jpain.org/article/S1526-5900(15)00837-8/fulltext
● Effects of Vaporized Marijuana on Neuropathic Pain – Study Results – https://www.clinicaltrials.gov/ct2/show/results/NCT01037088
● An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease – https://www.ncbi.nlm.nih.gov/pubmed/27286745
● Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review – http://www.bmj.com/content/323/7303/13
● Prescribing cannabis for harm reduction – https://harmreductionjournal.biomedcentral.com/articles/10.1186/1477-751...
● Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268094/
● Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755639/
● Cannabinoids for Neuropathic Pain – https://www.ncbi.nlm.nih.gov/pubmed/25160710
● Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243008/
● Cannabinoids in the management of difficult to treat pain – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
● Role of Cannabinoids in Pain Management – http://cannabisclinicians.org/role-of-cannabinoids-in-pain-management/
● Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371734/
● Smoked cannabis for chronic neuropathic pain: a randomized controlled trial – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950205/
● Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain – http://www.jpain.org/article/S1526-5900%2812%2900864-4/abstract
● Effects of Delta-9-Tetrahydrocannabinol and Cannabidiol on Cisplatin-Induced Neuropathy in Mice – https://www.ncbi.nlm.nih.gov/pubmed/27214593
● Cannabis as an Adjunct to or Substitute for Opiates in the Treatment of Chronic Pain – http://www.tandfonline.com/doi/abs/10.1080/02791072.2012.684624
● Involvement of the endocannabinoid system in osteoarthritis pain – https://www.ncbi.nlm.nih.gov/pubmed/24494687
● Neuropathic orofacial pain: cannabinoids as a therapeutic avenue – https://www.ncbi.nlm.nih.gov/pubmed/25150831
● Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis – https://www.ncbi.nlm.nih.gov/pubmed/16186518
● Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial – https://www.ncbi.nlm.nih.gov/pubmed/17997224
● The Endocannabinoid System, Cannabinoids, and Pain – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820295/
● Therapeutic potential of cannabis in pain medicine – http://bja.oxfordjournals.org/content/101/1/59.full
● Use of cannabinoids in cancer care: palliative care – http://www.current-oncology.com/index.php/oncology/article/view/2962/2087
● Why U.S. Doctors Love Opioids and Hate Marijuana for Chronic Pain – http://labblog.uofmhealth.org/rounds/why-us-doctors-love-opioids-and-hat...
● Neuropathic Pain – https://www.projectcbd.org/neuropathic-pain

→ PADACZKA

● Marijuana-Derived Epilepsy Drug in Clinical Trial for Children with Uncontrolled Seizures – http://www.ucsf.edu/news/2014/02/111641/marijuana-derived-epilepsy-drug-...
● The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy – http://jpet.aspetjournals.org/content/307/1/129.long
● Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/25845492
● Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex – https://www.ncbi.nlm.nih.gov/pubmed/27696387
● Cannabidiol: Pharmacology and potential therapeutic rolein epilepsy and other neuropsychiatric disorders – http://onlinelibrary.wiley.com/doi/10.1111/epi.12631/epdf
● The case for medical marijuana in epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/epdf
● The cannabinoids as potential antiepileptics – http://www.ncbi.nlm.nih.gov/pubmed/6975285
● Medical Marijuana Extract Curbs Seizure Frequency in Early Trial of Epilepsy Patients – http://nyulangone.org/press-releases/medical-marijuana-extract-curbs-sei...
● Marijuana use in adults admitted to a Canadian epilepsy monitoring unit – https://www.ncbi.nlm.nih.gov/pubmed/27568641
● Cannabis anti-convulsant shakes up epilepsy treatment – https://www.newscientist.com/article/dn22263-cannabis-anti-convulsant-sh...
● Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures – http://www.seizure-journal.com/article/S1059-1311(12)00057-X/fulltext
● Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol – https://www.ncbi.nlm.nih.gov/pubmed/27267376
● Slim Evidence for Cannabinoids for Epilepsy – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639568/
● Pharmaceutical CBD (cannabidiol) shows promise for children with severe epilepsy – http://www.sciencedaily.com/releases/2015/12/151207145856.htm
● Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial – http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(15)00379-8/abstract
● Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases – https://www.ncbi.nlm.nih.gov/pubmed/27655472
● Cannabinoids: is there a potential treatment role in epilepsy? – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845642/
● Cannabinoids for epilepsy – http://www.ncbi.nlm.nih.gov/pubmed/22696383
● CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience – https://www.ncbi.nlm.nih.gov/pubmed/26800377
● Cannabis and other illicit drug use in epilepsy patients – http://www.ncbi.nlm.nih.gov/pubmed/23311572
● Efficacy and safety of epidiolex (cannabidiol) in children and young adults with treatment-resistant epilepsy: update from the expanded access program – https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/241...
● Long-term efficacy and tolerability of add-on cannabidiol for drug-resistant pediatric epilepsies – https://www.aesnet.org/meetings_events/annual_meeting_abstracts/view/232...
● Fewer specialists support using medical marijuana andCBD in treating epilepsy patients compared with othermedical professionals and patients: Result of Epilepsia’ssurvey – http://onlinelibrary.wiley.com/doi/10.1111/epi.12843/epdf
● Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/
● The case for medical marijuana in epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/epi.12610/full
● Temporal characterization of changes in hippocampal cannabinoid CB1 receptor expression following pilocarpine-induced status epilepticus – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841984/
● Phytocannabinoids and epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/25475762
● Duration of use of oral cannabis extract in a cohort of pediatric epilepsy patients – https://www.ncbi.nlm.nih.gov/pubmed/27859038
● Patient use of cannabis in epilepsy – https://www.sciencedaily.com/releases/2014/12/141208144146.htm
● Medical Marijuana and Epilepsy – http://www.epilepsy.com/learn/treating-seizures-and-epilepsy/other-treat...
● Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol – http://journal.frontiersin.org/article/10.3389/fphar.2016.00359/full
● Cerebrospinal fluid levels of the endocannabinoid anandamide are reduced in patients with untreated newly diagnosed temporal lobe epilepsy – http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02334.x/full
● Chronic administration of cannabidiol to healthy volunteers and epileptic patients – https://www.ncbi.nlm.nih.gov/pubmed/7413719
● The Pharmacological Basis of Cannabis Therapy for Epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/26787773
● Cannabis and Endocannabinoid Signaling in Epilepsy – https://www.ncbi.nlm.nih.gov/pubmed/26408165
● Cannabidiol: Promise and Pitfalls – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189631/
● Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707667/
● Cannabidiol for Intractable Epilepsy: Promising Open-label Results Increase Interest in Forthcoming Blinded Trials – http://journals.lww.com/neurotodayonline/Fulltext/2016/02040/Cannabidiol...
● AHP Releases Cannabis in the Management and Treatment of Seizures and Epilepsy: A Scientific Review – https://www.naturalproductsinsider.com/news/2014/03/ahp-releases-review-...
● Clinical Experience With Cannabis In Treatment-Resistant Pediatric Epilepsy – http://docplayer.net/21578411-Clinical-experience-with-cannabis-in-treat...
● Cannabis in the Treatment of Pediatric Epilepsy – http://theroc.us/images/Cannabis in the Treatment of Pediatric Epilepsy.pdf
● Endocannabinoid system protects against cryptogenic seizures – https://www.ncbi.nlm.nih.gov/pubmed/21441624
● Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157067/
● Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome – http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804326/
● Anti-Convulsant Properties of Cannabis Extract is NOT a New Discovery – http://epilepsyu.com/blog/anti-convulsant-properties-cannabis-extract-ne...
● CENSORED: 1947 Cannabis Study on Epilepsy – http://weedfinder.com/dash/news/censored-1947-cannabis-study-on-epilepsy/

………………..

W sobotę będziemy rozmawiali na temat stosowania kannabinoidów w onkologii. Dla tych od „nie ma badań” też przygotowałem trochę linków – tym razem do stron, na których zbiorczo przedstawiono informacje o różnych badaniach z tego obszaru. Niestety, poza paroma wyjątkami nie są to badania kliniczne. Będę o tym mówił w moim wystąpieniu na konferencji.

→ RAK

● 123 Studies Show Cannabis Prohibition Is Killing Cancer Patients – http://www.exposingtruth.com/123-cannabis-cancer/
● 20 Medical Studies that prove cannabis can cure cancer – http://londoncannabisclub.com/20-medical-studies-prove-cannabis-can-cure...
● 20 Medical Studies That Show Cannabis Can Be A Potential Cure For Cancer – http://www.collective-evolution.com/2013/08/23/20-medical-studies-that-p...
● 34 Studies showing cannabis can cure cancer – http://www.cureyourowncancer.org/cannabis-can-cure-many-forms-of-cancer....
● 4 Studies Proving that Marijuana can Treat Brain Cancer – http://naturalsociety.com/4-studies-marijuana-treat-brain-cancer/
● 64 Studies That Show Cannabis Can Treat Various Cancers – https://thejointblog.com/61-studies-show-cannabis-can-treat-various-canc...
● 68 studies on the efficiency of marijuana against cancer- http://www.alchimiaweb.com/blogen/68-studies-efficiency-marijuana-agains...
● 700 medicinal uses of cannabis sorted by disease – http://www.encod.org/info/700-MEDICINAL-USES-OF-CANNABIS.html
● 9 types of cancer that can be killed by cannabis – http://healthycures.org/9-types-of-cancer-that-can-be-killed-by-cannabis/
● Cannabis Cures – 121 Studies Cannabinoids Kill Cancer cells – http://thecannabiscure.blogspot.com/2015/01/121-studies-cannabinoids-kil...
● Lista 34 badań medycznych dowodzących skuteczność wykorzystywania konopi w terapii nowotworów – http://konopielecza.pl/lista-34-badan-medycznych-dowodzacych-skutecznosc...
● Marihuana leczy raka! – czyli 20 badań medycznych potwierdzających lecznicze właściwości konopi – http://www.medicoland.pl/artykuly/100/marihuana-leczy-rakaczyli-20-badan...
● Over 100 Scientific Studies Agree: Cannabis Annihilates Cancer – http://wakeup-world.com/2015/05/17/over-100-scientific-studies-agree-can...
● The Top 42 Medical Studies That Prove Cannabis Cures Cancer – http://www.hempforfuture.com/2014/05/12/the-top-42-medical-studies-that-...
● There Are Now 100 Scientific Studies That Prove Cannabis Cures Cancer – http://higherperspectives.com/cannabis-cures-cancer/