Hydroxyzine has beneficial effects listed in this article but stands out in this pharmacotherapeutic category for its virtually non-existent addiction liability. The piperazine class of antihistamines is the fourth or even lower of the seven categories of first-generation antihistamines in the generation of euphoria in patients. The euphoria, which is mild (certainly not at the same level as morphine &c.) and tends to be either transient or long-lasting, appears to be part of the impact either direct or indirect on dopamine, acetylcholine, and possibly serotonin, norepinephrine, and even endorphin levels and ratios and possible activation of parts of the NMDA systems. Therefore, it would also stand to reason that it is reinforced by the alleviation of discomfort, much in the same way as some people experiencing transient euphoria after taking ibuprofen or naproxen. The ethanolamines (diphenhydramine, orphenadrine, dimenhydrinate, carbinoxamine and others) and alkylamines (triprolidine, pheniramine, brompheniramine, chlorpheniramine and others) are the strongest euphoriants amongst antihistamines and some ethylenediamines like pyrilamine and tripelennamine are on the list as well.

Function

Inositol as the basis for a number of signaling and secondary messenger molecules, is involved in a number of biological processes, including:
Insulin signal transduction[3]
Cytoskeleton assembly
Nerve guidance (Epsin)
Intracellular calcium (Ca2+) concentration control[citation needed]
Cell membrane potential maintenance[citation needed]
Serotonin activity modulation
Breakdown of fats and reducing blood cholesterol[citation needed]
Gene expression[4][5]