Have received 2 different samples of Bromadoline (U-47931E) for analysis.

The first is a white crystalline powder, the second a tan crystalline powder.

Most reports I’ve seen on this compound are basically that it is inactive. This is definitely not the case with either sample.

Subject had no tolerance after 2 weeks of abstaining. Started with an allergy test of the first sample (white), and gradually titrated up to a total of 80mg over the course of a few hours, all consumed via insufflation. 80mg (combined) is when effects moved from potentially placebo to confirmed threshold. Subject insufflated another 80mgs as effects were still hardly noticeable.

No appreciable rush was experienced, come up was strangely slow despite the ROA, but within 20 minutes of insufflating 80mg (combined total of 160mg over 3-4 hours) all standard opioid effects were noted by subject; itchiness, pupil constriction, and of course euphoria.

Duration seems short, and redosing compulsive. Also, subject noted some chest tightness, a negative side-effect only previously experienced with U-47700.

Analysis of the second sample (tan), starting with an allergy test and slowly titrating up, began but only as redoses for the first sample. This second sample was reportedly maleate form, and it is unclear whether the first sample was freebase, hcl, maleate, etc... as the vendor did not indicate (free sample). A rush was noted with the second sample, but it is unclear if this will be the case if subject starts at baseline. Will research this second sample by itself and update.

Conclusion thus far, first sample of Bromadoline seems less potent than indicated (Wikipedia says 70% as potent as morphine) but is definitely active. No meaningful rush and some negative side-effects, less potent and shorter legs than O-DSMT.

Experiments with second sample, second subject, other ROAs, etc... will continue and I will update this post.

Update 1: Second subject tested oral dosages, titrating slowly up to a total of 100mg of sample number one (white), with nothing beyond some analgesia noted as an outcome.

Update 2: Subject 1 insufflated 40mg of sample 2 (tan / brown), allergy tests and low dose titration having been completed the previous evening. Moderate rush and Euphoria noticed with this sample in this dosage range. Definitely well above threshold but still in a low dosage range.

Subject 1 insufflated 80mg more of sample 2 approximately 3 hours later as primary effects were wearing off. Profound rush and solid euphoria. Definitely not a high dosage, likely mid to strong, but reportedly quite enjoyable.

Subject 2 ingested 40mg of sample 2 (tan / brown) orally, experiencing euphoria and pronounced analgesia along with normal side-effects such as itchiness and pupil constriction.

It appears that sample 2 (tan / brown) is far more potent than sample 1 (white) by both ROAs that have been tested thus far.

Update 3: Sample 2 (tan / brown) is exactly what the available research suggests Bromadoline should be. Selective for the mu opioid receptors and approximately 70% the potency of morphine. Not sure what to make of sample 1 (white) as it seems to have a high affinity for kappa receptors and definitely lacks the expected potency.