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,4-Methylenedioxy-N-hydroxy-N-methylamphetamine (MDHMA; FLEA) is an entactogen, psychedelic, and stimulant of the phenethylamine and amphetamine chemical classes. It is the N-hydroxy homologue of MDMA ("ecstasy"), and the N-methyl homologue of MDOH. MDHMA was first synthesized and assayed by Alexander Shulgin.[1] In his book PiHKAL (Phenethylamines i Have Known And Loved), Shulgin listed the dosage range as 100–160 mg, and the duration as approximately 4–8 hours.[2] He describes MDHMA as causing entactogenic and open MDMA-like effects, easing communication, and increasing appreciation of the senses.[3]

This chemical will act similar to amphetamine. The pathways more open however will display a releasing magnitude at the Serotonin 1a and 1b. Acting as a releasing agent at the Serotonin 1a and a selective electroplasmic releasing agent at the 1b. Having full ability for release of neurotransmitters at the 1b creates much magnetic draw. MDHMA releases alongside dopamine though the 1a receptor and 1b receptor. Having a higher affinity for the 1b receptor. These chemicals having a magnetic charge from base, draw magnitude and antagonism to the 2c receptor. Leaving the pathway magnetized at the 2a receptor and having weak agonism at the 2b receptor. Cleaving the pathway for 2a agonism leads GABA toward the 1a receptor for release at 1a and 1b, later releases serotonin again from the 1b receptor and the 1a receptor. Endorphins follow this pathway and oxytocin is squeezed from the synapse to be metabolized at magnetic amplitude.
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