5zł pisze:

mam kilka pytan odnosnie tej substancji.
Moj znajomy jara trawke praktycznie codziennie od 3 lat. ogolnie nie wyobraza sobie pojsc spac bez hita przed snem :)
Czy 5-htp w dawkach 200 mg przed snem moglo by mu pomoc? Probowal juz przestac palic jednak nigdy z dobrym skutkiem najwiecej wytrzymal kilka dni ale ciezko bylo mu zasnac.Do tego dochodzi obnizenie motywacji i zaniedbanie takich podsatawowcyh rzeczy jak uczelnia itp itp... Czekam na odp
pozdro

This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on:
-the availability of tryptophan
-and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine
2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Factors affecting each of these are reviewed. The amount of 5-HTP reaching the central nervous system (CNS) is affected by the extent to which 5-HTP is converted to serotonin in the periphery. This conversion is controlled by the enzyme amino acid decarboxylase, which, in the periphery, can be blocked by peripheral decarboxylase inhibitors (PDIs) such as carbidopa.

EGCG will work similary to carbidopa. It will inhibit that enzyme resonsible in breaking down 5-htp before it reaches the brain.

It is my understanding that ECGC effectively inhibits aromatic L-amino acid decarboxylase in both peripheral and nervous tissue, allowing for 5-HTP to cross the blood brain barrier before being destroyed. Since ECGC also crosses the BBB, I assume the 5-HTP that crosses will remain mostly intact in the brain until the ECGC itself is metabolized (its half life being only a few hours). Next, the disinhibited aromatic L-amino acid decarboxylase metabolizes the 5-HTP to serotonin, thereby helping to replenish reserves.