Na przykład, wartość i K dla tetrahydrokanabinolu (THC) jest równa 10,2 nM, a syntetycznego JWH-387 - 43 nm. W związku z tym powinowactwo do receptorów CB1 JWH-387 jest słabsze niż naturalny odpowiednik o 4(!!) razy. Jak substancja ma więcej niż 100 w kolumbie "K (nM)" to znaczy że jest niemalże nie aktywna.

ITT: I'm going to give you some of the science behind allot of the popular synthetic cannabinoids, along with some personal notes and experience I have with them.

I'm making this thread because I see a ton of threads pop up asking about "is JWH-XXX legit, is it better then JWH-XXX" ect ect.

First off I'll explain terms I'll be using:

> Ki: Binding affinity/Equilibrium dissociation constant
In simple terms, a lower Ki == a greater affinity. Molecules with higher affinities for target proteins usually require lower doses(/concentrations).

So the lower the Ki value generally means a smaller dose will be required. It doesn't translate 100% because there's a lot more involved then just the receptor and the chemical but it's still a useful indicator.

The affinity ratio is just a way to show how a chemical might be more active at one receptor/protein sub-type then the other. Of course it's also more complicated then that, but it's a rough indicator.

> CB1r, and CB2r
The CB1r is the Cannabinoid receptor which is more widely expressed in the central nervous system (e.g. brain). Its modulation likely accounts for the psychoactive effects of Cannabinoids (altered time perception, anxiety/anxiolysis, depersonalization, heightened creativity, enhanced well-being, visual/auditory distortions/hallucinations...etc.). It may also play a role in some of the analgesic properties of Cannabinoids. In general, compounds with higher CB1/2 ratios are more prone (as compared to a compound with a higher CB2/1 ratio) to anxiety/panic-attacks, hallucinations, and other psychoactive extremes.

Well now that we got that of the way lets break down some of the big names:
Lets start with the JWH-XXX series.

> JWH-018 | CB1 Ki 9.0nM | CB2 Ki 2.94nM
Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).

> JWH-073 | CB1 Ki 8.9nM| CB2 Ki 38nM
JWH 073 is a mildly selective agonist of the central cannabinoid (CB1) receptor derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding CB1 and the peripheral cannabinoid (CB2) receptor are 8.9 and 38 nM, respectively for a CB1:CB2 ratio of 0.23.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2 when tested in rats.

> JWH-081 | CB1 Ki 1.2nM| CB2 Ki 12.4nM
JWH-081, the N-pentyl analog of 28, R=C5H11, has very high affinty for the CB1 receptor with Ki=1.2+/-0.1 nM and is very potent in vivo.

> JWH-133 | CB1 Ki --- | CB2 Ki 3.4nM
Potent CB2 selective agonist (Ki = 3.4 nM). Approx. 200-fold selective over CB1 receptors. Active in vivo, reducing spasticity in a murine model of multiple sclerosis.

> JWH-200 | CB1 42nM | CB2 Ki ---
acts as a cannabinoid receptor agonist. Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC, but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect, most likely reflecting favourable pharmacokinetic characteristics.

> JWH-250 | CB1 Ki 11nM | CB2 Ki 33nM
JWH 250 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) and the peripheral cannabinoid (CB2) receptors. The affinities of JWH 250 for both CB1 (Ki = 11 nM) and CB2 (Ki = 33 nM) are comparable to those of the traditional cannabinoids.

> JWH-122 | CB1 Ki 0.69 | CB2 Ki 1.2
(only personal notes here) Very high affinity to both the CB1 and CB2 receptors, with a about twice the affinity in the CB1 receptor, giving JWH-122 an almost psychedelic high in even small doses(1-4mg).

> JWH-019 | CB1 Ki 9.80nM | CB2 Ki 5.55
(only personal notes here) very similar to JWH-018, with more of an affinity toward CB1 receptor, giving more of a "head high", respectively.

> JWH-210 | CB1 Ki 0.46nM | CB2 Ki 0.69
(haven't tried this one first hand) It can be assumed that JWH-210 has similar effects and dosing to JWH-122, with only a lightly higher "body high" per concentration.

Also for reference purposes:
> Δ9-tetrahydrocannabinol(Δ9THC) | CB1 Ki 15.30nM | CB2 Ki 25.06nM
I included this, so you can use it as a gross estimate of how potent the other cannabinoids are. Also Δ9THC has CB1/CB2 ratio of about 3/5, this isn't to say it's the "best" ratio, but being as many people using synthetic cannabinoids or trying to duplicate the Δ9THC experience, it's a good base to start from.

Somatic pisze:

a może nie wyszło bo rozrabiałem w wódce zamiast spirytusie? (wódkę miałem pod ręką, nie chciałem specjalnie spirytu kupować)

borsuk00 pisze:

Wie może ktoś czym nasączyć liście podbiału, aby miały aromatyczny smak?
Próbowałem aromatem do ciasta. Pachniało ładnie, ale tylko przed zapaleniem. Poz zapaleniu czuć niezbyt przyjemny aromat.

Wikipedia pisze:

(...) Its binding affinity at the CB1 receptor is 42nM, around the same as that of THC, but interestingly, its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro, around 3 times that of THC but with less sedative effect (...) ==>

Wikipedia pisze:

(...) Cannabinoid agonist with approximately equal affinity at both the CB1 and CB2 receptors, having a Ki of 8.0nM at CB1 and 7.0nM at CB2. (...) ==>