randomuser811 pisze:

a ja sądzę że ma, bo śluzówki jamy ustnej mają b.dobrą przepuszczalność

slim pisze:

nie robilem tak ale nie sadze zeby i tak mialo to sens ze wzgledu na dawke. (...)

JWH-015 is a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1. However it still displays some weak CB1 activity. It has been shown to possess immunomodulatory effects and CB2 agonists may be useful in the treatment of pain and inflammation.

Aung MM, Griffin G, Huffman JW, Wu MJ, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 2000; 60:133-140 ([url=http://www.drugs-forum.com/forum/local_links.php?action=ratelink&catid=51&linkid=6310]drugs-forum.com PDF[/url]) pisze:

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Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3([url=http://www.drugs-forum.com/forum/local_links.php?action=ratelink&catid=51&linkid=6328]drugs-forum.com PDF[/url]) pisze:

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JWH-015 has been shown in vitro to be metabolised primarily by hydroxylation and N- dealkylation , and also by epoxidation of the naphthalene ring, [ 7 ] similar to the metabolic pathways seen for other aminoalkylindole cannabinoids such as WIN 55,212-2 . [ 8 ] Epoxidation of polycyclic aromatic hydrocarbons can produce carcinogenic metabolites, although there is no evidence to show that JWH-015 or other aminoalkylindole cannabinoids are actually carcinogenic in vivo .

Blefujesz pisze:

JWH-015 is a chemical from the naphthoylindole family, which acts as a subtype-selective cannabinoid agonist. Its affinity for CB2 receptors is 13.8nM, while its affinity for CB1 is 383nM, meaning that it binds almost 28x more strongly to CB2 than CB1. However it still displays some weak CB1 activity. It has been shown to possess immunomodulatory effects and CB2 agonists may be useful in the treatment of pain and inflammation.

to znaczy że nie działa tak jak powinien... tak? o 251 nie doczytałem nic narazie

Komórki mikrogleju - makro fagi mózgowe - posiadają poza CB1 jeszcze dwa inne receptoiy kanabinoidowe CB2 oraz abn_CBD ("nieprawidłowo" wrażliwe na kanabidiol), odpowiedzialne za regulację migracji tychże komórek.

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