The Blood Brain Barrier is more permeable to lipids (fats), fats cross it more rapidly.
Opiates are almost always lipid soluble also, specially the free bases. Maybe opiates dissolve or merge molecules in/to fats after doing them with a fat meal or ingesting a fat meal while they are absorving from the G.I. tract. So... Maybe... The opiates molecules merged with fats are more lipid soluble and because of that they can cross the blood brain barrier quicker.

For an example: look how heroin (diamorfine) is about 2.2 times more powerful then morphine, all because its more lipid soluble and because of that enters the BBB more rapidly and then is almost instantly converted to morphine, so its the morfine thats causing the effects mostly but the more rapid entry made it 2.2times more powerfull.

Read more: http://www.drugs-forum.com/forum/showth ... z2hMhzny20

One OxyContin 160 mg tablet is comparable to two 80 mg tablets when taken on an empty stomach. With a high-fat meal, however, there is a 25% greater peak plasma concentration following one 160 mg tablet. Dietary caution should be taken when patients are initially titrated to 160 mg tablets (see DOSAGE AND ADMINISTRATION).

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